5月22日，中荷生物医学与信息工程学院邀请荷兰埃因霍温科技大学Ossenblok教授来院交流，开展了题为“癫痫研究中自发性脑活动的多模态窗口”的学术报告。

  Ossenblok教授认为脑磁图（MEG）和脑电图（EEG）信号都是由局部皮层神经元的原始电流产生的，而功能核磁共振成像通常视为神经功能的标记。研究表明，神经系统（neural）和血氧依赖水平（BOLD）是两种不同的方法，二者一起应用可提供更全面的大脑活动图像。EEG、MEG和脑电图相关的功能性核磁共振（EEG-fMRI）的成像结果将会用于治疗癫痫病的病人。MEG倾向于将癫痫发作（IEDs）的开始定位；网络分析显示，EEG和FMRI的活动模式包含由网络中Hub驱动的相互作用且高度相关的大脑区域。未来研究的问题是如何在不预先知道病人癫痫的情况下识别Hub。

  5月24日，Ossenblok教授作了题为“创伤最小化的癫痫治疗”的报告，介绍了对癫痫病人的治疗正在由开放侵入的方式转变成尽可能小的侵入式和图像指导治疗。目前已开发出多模态大脑成像软件，可应用于术前确定病人大脑中负责癫痫的脑区，最终目标是给神经外科医生提供癫痫区域清晰直观的影像图片。

  在场师生对创伤最小化治疗这一课题表示出浓厚兴趣，踊跃提问，Ossenblok教授一一耐心解答。

Aboutthe speaker:

PaulyOssenblok has been working after finishing her PhD study as a medicalphysicist, focusing on Research & Development of brain imaging techniquesand the application of these techniques for patient studies, mainly inepilepsy. Originally she started in clinical neurophysiology with as mainapplications source analysis of high resolution EEG, but switched in an earlyphase to MEG as a valuable tool for the diagnosis and treatment of epilepsy.Her activities also include EEG combined functional MRI and structuraldiffusion-weighted MRI techniques and network analysis based on thesetechniques. More recently she extended her functional EEG and MRI studies withthe study of the excitability of the brain using combined TranscranialMagneticStimulation, EMG and EEG. (TMS-EMG/EEG).

PaulyOssenblok authored over 40 peer reviewed scientific papers and a number of bookchapters (Appendix A), she achieved a good number of grants, has extensiveexperience in teaching (lectures) and supervising of master and PhD studentsand postdocsand a more than 100 proceedings contributions related topresentations at international conferences. She is reviewer of many journals,organized a number of scientific sessions at international conferences andsymposia and was invited as a speaker or guest.