孙建军教授12月23日13:00-13:50学术报告
孙建军教授为美国德州大学教授。孙建军教授于23日13:00-13:50，在生科楼B619做学术报告，请感兴趣的老师参加。
报告的题目：Mycobacterium tuberculosis ESAT-6: a single molecular target for tuberculosis prevention, diagnosis and treatment.
内容：The 6-kDa early secreted antigenic target (ESAT-6) is an essential virulence factor for pathogenesis of Mycobacterium tuberculosis (Mtb). Through its membrane-interacting activity, ESAT-6 mediates translocation of Mtb from the phagosomes to the cytosol within host macrophages, a critical step in the transition of a latent infection to active tuberculosis (TB) diseases. Thus, ESAT-6 is an important therapeutic target for inhibiting the transition from latent to active TB. ESAT-6 is also a potent T-cell antigen and uniquely present in virulent mycobacterial species, but not in avirulent species, such as TB vaccine strains, which makes ESAT-6 an excellent candidate for development of novel vaccines and diagnosis against TB. The ESAT-6-centered research in Dr. Sun’s laboratory is integrating multidisciplinary approaches to investigate the mechanism of ESAT-6 membrane interaction and develop novel vaccines and diagnostic approaches to fight the global TB epidemics.
孙建军教授为美国德州大学教授。孙建军教授于23日13:00-13:50，在生科楼B619做学术报告，请感兴趣的老师参加。
报告的题目：Mycobacterium tuberculosis ESAT-6: a single molecular target for tuberculosis prevention, diagnosis and treatment.
内容：The 6-kDa early secreted antigenic target (ESAT-6) is an essential virulence factor for pathogenesis of Mycobacterium tuberculosis (Mtb). Through its membrane-interacting activity, ESAT-6 mediates translocation of Mtb from the phagosomes to the cytosol within host macrophages, a critical step in the transition of a latent infection to active tuberculosis (TB) diseases. Thus, ESAT-6 is an important therapeutic target for inhibiting the transition from latent to active TB. ESAT-6 is also a potent T-cell antigen and uniquely present in virulent mycobacterial species, but not in avirulent species, such as TB vaccine strains, which makes ESAT-6 an excellent candidate for development of novel vaccines and diagnosis against TB. The ESAT-6-centered research in Dr. Sun’s laboratory is integrating multidisciplinary approaches to investigate the mechanism of ESAT-6 membrane interaction and develop novel vaccines and diagnostic approaches to fight the global TB epidemics.
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